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Association of Opioid Type with Opioid Consumption after Surgery

  • Patients prescribed hydrocodone consumed 7 tablets (95% CI 6.79-7.18) while patients prescribed oxycodone consumed 6 tablets (95% CI 5.58-6.40.)
  • Although patients prescribed hydrocodone consumed more tablets than patients prescribed oxycodone, this difference was not clinically significant and did not result in differences in satisfaction, pain, or refills.
  • Perioperative opioid prescribing guidelines may recommend the same number of 5 mg oxycodone and hydrocodone tablets without sacrificing patient-reported outcomes.


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Zikovich S; Gunaseelan V; Englesbe MJ; Waljee JF; Brummett CM. Association of Opioid Type with Opioid Consumption after Surgery. Annals of Surgery. Published online 10 February 2021. DOI: 10.1097/SLA.0000000000004793