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New persistent opioid use after surgery in patients with a history of remote opioid use

  • Among patients not using opioids preoperatively, a history of opioid use was independently associated with new persistent opioid use after surgery, especially those with a history of continuous opioid use.
  • Similarly, history of opioid use was independently associated with opioid prescription refill at 1 month after surgery.
  • Moderate to high alcohol use was associated with new persistent use as well as opioid prescription refill at 1 month


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Agarwal S, Shah A, Gunaseelan V, Sulich C, McAfee J, Urquhart AG, As-Sanie S, Lin J, Waljee JF, Brummett CM. New persistent opioid use after surgery in patients with a history of remote opioid use. Surgery Journal. Published online 8 December 2021. DOI: 10.1016/j.surg.2021.11.008