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Preoperative Opioid Use is Independently Associated with Increased Costs and Worse Outcomes After Major Abdominal Surgery

  • The study considered patients at a single center having abdominopelvic surgeries (appendectomy, cholecystectomy, gynecologic and bowel procedures, etc.) and found that patients using opioids preoperatively had 9.2% higher costs.
  • Patients with preoperative opioid use had longer length of stay at the hospital, more complications and more readmissions, indicating that preoperative opioid use is a modifiable risk factor for surgery.


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Cron DC, Englesbe MJ, Bolton CJ, et al. Preoperative Opioid Use is Independently Associated With Increased Costs and Worse Outcomes After Major Abdominal Surgery. Ann Surg. 2017;265(4):695-701. doi:10.1097/SLA.0000000000001901