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Preoperative Opioid Use and Mortality After Minor Outpatient Surgery

  • Preoperative opioid use was correlated with an increased mortality within 90 days after surgery
  • Patients with high and medium preoperative opioid exposure were more likely to die within 90 days after outpatient surgery compared with opioid-naïve patients
  • Mortality did not differ between opioid-naïve patients and patients with low preoperative opioid exposure.


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Santosa KB, Lai Y, Oliver JD, et al. Preoperative Opioid Use and Mortality After Minor Outpatient Surgery. JAMA Surg. Published online October 21, 2020. doi:10.1001/jamasurg.2020.3623