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Association of Hydrocodone Schedule Change with Opioid Prescriptions Following Surgery

  • After hydrocodone was changed from a schedule III to schedule II controlled substance, the mean OMEs filled in the initial opioid prescription increased by approximately 35 OMEs, equivalent to 7 tablets of hydrocodone.
  • Opioid-related policies, and any subsequent edits, must be closely monitored to identify unintended effects.

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Habbouche J, Lee J, Steiger R, et al. Association of Hydrocodone Schedule Change With Opioid Prescriptions Following Surgery [published correction appears in JAMA Surg. 2018 Dec 1;153(12):1164]. JAMA Surg. 2018;153(12):1111-1119. doi:10.1001/jamasurg.2018.2651