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Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder

  • Persistent opioid use after surgery is a common morbidity outcome associated with subsequent opioid use disorder, overdose, and death.
  • We conducted the largest genetic study of persistent opioid use after surgery, comprising ~40,000 non-Hispanic, European-ancestry Michigan Genomics Initiative participants (3198 cases and 36,321 surgically exposed controls).
  • Associations at previously identified OPRM1 variants suggest common biology between persistent opioid use and opioid use disorder, further demonstrating connections between opioid dependence and addiction phenotypes.

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Annis, A. C., Gunaseelan, V., Smith, A. V., Abecasis, G. R., Larach, D. B., Zawistowski, M., Frangakis, S. G., & Brummett, C. M. (2025). Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder. Genetic epidemiology, 49(1), e22588. https://doi.org/10.1002/gepi.22588