Not all people who use drugs (PWUD) are ready to stop or enter into treatment. A harm reduction approach can help you adopt safer strategies until you can take the next step.
OPEN’s harm reduction educational materials are created in collaboration with people with lived experience.
Get the answers you need to the following questions:
Harm reduction focuses on individual well being. Following these practices when possible while using drugs can help keep you safe:

Naloxone (Narcan®) is a lifesaving drug that rapidly and temporarily reverses the dangerous effects of an opioid overdose. It works if you have opioids such as fentanyl, heroin, and prescription opioids in your body.
Some things to know:
Fentanyl is an extremely powerful opioid – even a small amount can cause a fatal overdose. You can use test strips to test for the presence of fentanyl and reduce your risk. Watch the video to learn the simple steps:
Also known as tranq, xylazine is becoming more common in the unregulated opioid supply. Because it’s a drug meant to put large animals to sleep, it is not intended for human use and it can have serious side effects – including wounds that require immediate attention and care.
It’s not clear why xylazine causes wounds. It’s important to know they can pop up anywhere on the body, no matter if you inject, smoke, snort, or boof.
Get medical care as soon as possible if you have wounds along with any of these symptoms:
Go to the emergency room immediately if you have wounds along with any of these symptoms:
Access to clean needles and syringes is important to prevent infections and other complications such as HIV and hepatitis. Syringe Services Programs are community based and provide services such as linkage to substance use treatment, vaccination, testing, and education about overdose prevention and safer injection practices while also screening and testing for HIV and hepatitis.
Find a Syringe Services Program near you.
Harm reduction can help keep you safe and sometimes be the bridge to the path to recovery. If you’re looking for support, call the SAMHSA National Helpline, a free, confidential, 24/7, 365 day-a-year treatment referral and information service for anyone facing mental or substance use disorders.
CALL: 1-800-662-HELP (4357)
The Overdose Prevention Engagement Network (OPEN) is dedicated to improving lives and reducing harms of substance use. We share education and resources to strengthen person-centered prevention, treatment, and recovery.