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Michigan OPEN


OPEN is working to reduce opioid-related deaths by expanding access to naloxone among high-risk populations. Our strategy is to collaborate with organizations and institutions across Michigan to distribute naloxone and get this life saving medication into the hands of patients, family members, caregivers and communities who are at high risk of opioid overdose. 

What is Naloxone?

  • Naloxone (Narcan®) is a drug that rapidly and temporarily reverses the dangerous effects of an opioid overdose.
  • It works if you have opioids in your body such as fentanyl, heroin & prescription opioids.
  • Naloxone can be given every 2-3 minutes until the person breathes again.
  • A person cannot get high or become addicted to naloxone.
  • Effective Only for 30 – 120 minutes.


What are the different types of naloxone?

Nasal Spray (Narcan)
Duration of Action30-90 minutes20-120 minutes
Repeat DosingEvery 2-3 minutesEvery 2-3 minutes
Assembly Supplies Needed#2, 3 mL syringe w/ 23-25 gauge 1-1.5 inch IM needlesNone
SIG for Suspected OverdoseInject 0.4 mg (1 mL) IM x1. Repeat every 2-3 minutes until patient is responsive or EMS arrives1 actuation in one nostril x2. Repeat every 2-3 minutes until patient is responsive or EMS arrives
Storage-Protect from light
-Room temperature - 68 °F to 77 °F
-Protect from light
-Room temperature - 68 °F to 77 °F
-Excursion allowed between 41 °F and 104 °F
-Freezes at temperatures below 5 °F and the device will not spray. Leave the device at room temperature for 15 minutes to thaw
How is it SuppliedSingle dose flip top vialCarton contains 2 blister packages of 4mg single use nasal spray
DisposalSharps containerAny waste container that is away from children
Direct Cost$30-40$169

Learn the Facts: Naloxone

Learn about naloxone and how to safely administer it.

How to use Naloxone

Instructions for Narcan® Intranasal Spray

Michigan law protects you from liability when giving naloxone and calling 911 for someone who is experiencing an overdose.

Step 1:
Peel from packaging.
Step 2:
Place the nozzle in the nose.
Step 3:
Push the plunger to spray.

Intranasal Naloxone for Laypeople

Intramuscular Naloxone

Safety Reminders:

  • Do not spray test spray
  • Do not delay calling 911
  • Do not inject the person with anything
  • Do not put the person in a bath or shower
  • Do not give the person anything to drink
  • Do not pour water over the person’s face

Take A.C.T.I.O.N. Training Courses

OPEN offers free, online and self-paced training to learn how to help someone experiencing an overdose.


First responders are key players in responding to our country’s opioid overdose epidemic. Take our First Responder Training to learn how to reverse an overdose.

Take the course!


Allies, community leaders, and those wanting to impact and save lives: take our Community Layperson Naloxone Training and learn how to take A.C.T.I.O.N to reverse an overdose.

Take the course!


Take A.C.T.I.O.N.

When someone is experiencing an overdose, every second matters. Knowing what to do—and quickly—can help save a life and give a person another opportunity for recovery. 

AArouse (3 S's)
  • Shout the person’s names
  • Shake shoulders vigorously
  • Sternal Rub: Rub breastbone with knuckles
CCheck for signs of overdose
  • Slowed or no breathing
  • Blue/gray lips or fingernails
  • Deep snoring/ gurgling noises
  • Unresponsive to pain
  • Pinpoint Pupils
TTelephone 911
  • Tell dispatch, “I think it’s an overdose”
  • Stay with the person until help arrives and it is safe
IIntranasal Naloxone
  • Give Naloxone
  • Do rescue breaths: Head back, Pinch nose, Lift chin, 1 breath every 5 seconds
  • OR CPR if you know how
  • OR follow dispatch instructions
NNaloxone again
  • Repeat naloxone every 2-3 minutes until the person starts to wake up
  • If you must leave the person, or vomiting occurs, place them in recovery position



Overdose Rescue Training Program

This program offers training sessions to those wanting to learn more about naloxone administration.

Where to Access Naloxone


  • Many community organizations distribute naloxone and other harm reduction materials for free.


  • If you are unable to access in-person naloxone distribution in your area, Next Distro offers naloxone shipped directly to your home in discreet packaging.
  • Available in English and Spanish.


  • Use the linked map to find locations of Naloxone vending machines in Michigan.


  • Naloxone can also be purchased at certain approved pharmacies without a prescription. 
  • MDHHS maintains a list of all the pharmacies approved to dispense naloxone through the standing order.

Implementing Naloxone in Emergency Departments

Prescribing naloxone to patients in the emergency department (ED) setting is recommended, legal, and within the scope of practice, carrying no more liability than the prescribing of other medications. ED-based naloxone distribution is impactful and cost effective. Organizations face several obstacles when establishing a program, including educating and training staff and lack of resources required to effectively introduce and sustain these evidence-based practices. This detailed guide is designed to facilitate implementation of your unique ED tailored naloxone distribution program.

Emergency Department Naloxone Implementation Guide

Learn how to facilitate and implement unique and tailored naloxone distribution programs in your Emergency Department.

Getting Started With Naloxone Distribution

  1. Create urgency to solve the problem
  2. Secure Project Sponsorship
  3. Set and Implement Project Aims

It is important to develop a team of members familiar with all the different aspects of building an ED naloxone program. Your team members can provide process improvement expertise and serve as champions for the work, advocating for naloxone distribution as a critical harm reduction intervention.

  1. Recruit Multidisciplinary Champions
    • Physician Champion
    • Nurse Champion
    • Pharmacist Champion
    • Social Work Champion
    • IT Champion
  2. As you form your multidisciplinary team with support from ED leadership, meet to discuss the following:
    • What competing ED priorities may prevent this project from getting started
    • Who will order naloxone for ED distribution? Or prescribe it?
    • Who will distribute naloxone to the patients?
    • Where will naloxone be stored and dispensed from?
    • Who will make the kits?
    • Who will educate staff on patient risk factors, overdose response, and naloxone use?
    • Who will educate patients on patient risk factors, overdose response, and naloxone use?
    • What is the role of in-house recovery specialists or addiction counselors?
    • Should the ED partner with outside agencies?
    • What is the funding source for naloxone?
  1. Identify a sustainable funding source(s) for NRKs
  2. Identify Naloxone Rescue Kit Components

Developing your Naloxone Distribution Protocol

Currently, no validated screening tools exist for acute care settings. The CDC and other studies have recommendations for identifying patients at higher risk for overdoses (see Box 2). Your team should decide which patient population will be targeted to receive naloxone rescue kits.

EHR prompts are associated with increased naloxone distribution for patients after overdoses. Work with your IT department to build order sets and alerts to facilitate the process.

By teaching your multidisciplinary team how to educate patients, anyone can address patient questions or concerns.

Consider the patient’s health literacy level as well as any reading or comprehension issues.

OPEN offers several free patient education resources (link or jump to resources section?).

Ideal Standard:

  1. Naloxone medication
  2. Pair of nonlatex gloves
  3. Barrier mask
  4. Blue kit label with a QR code to access patient video training
  5. Patient education brochure
  6. Local pharmacies participating in Michigan’s naloxone standing order program
  7. SUD treatment resources (not shown, site-specific, but required by law).


OPEN partners with MEDIC to increase access to naloxone by supplying emergency departments with take-home naloxone kits. Learn more about our partnership.

Emergency Department Naloxone Distribution Program

The Emergency Department Naloxone Program provides participating emergency departments in Michigan with naloxone rescue kits.